Authors: Putcha, Preeti, Jiyang Yu, Rodriguez-Barrueco, Ruth, Saucedo-Cuevas, Laura, Villagrasa, Patricia, Murga-Penas, Eva, Quayle, Steven, Yang, Min, Castro, Veronica, Llobet-Navas, David, Birnbaum, Daniel, Finetti, Pascal, Woodward, Wendy, FrançOis Bertucci, Alpaugh, Mary, Califano, Andrea, Silva, Jose

Venue: Figshare

Type: Dataset

Abstract: Quality control studies of the shRNA screens. a Representative image showing the Pearson and Spearman correlation among the triplicates for T = 10 in the SUM149 cell line. b GO-term and KEGG-pathway analyses using genes commonly depleted in several cell lines (p <0.05 in >=3 cell lines, 2,555 genes) show enrichment of genes related to essential functions. c Essential genes depleted in our shRNA screen cell lines overlapped significantly with compiled screens across 72 cell lines and subtypes of cancer (Fisherâ s exact test). (EPS 3172 kb... (read more)

DOI: 10.6084/m9.figshare.c.3646100_d3 (Found 2 versions)