BIP! Finder - Clinical relevance assessment of animal preclinical research (RAA) tool: development and explanation

2021 • Clinical relevance assessment of animal preclinical research (RAA) tool: development and explanation

Authors: Christian Gluud; Gavin Jell; Kiran Kumar Katakam; Miriam Dwek; Timothy D. McHugh; Carly C. Barron; Merel Ritskes-Hoitinga; Nicola J. Osborne; Brian R. Davidson; Kees van Laarhoven; Kurinchi Selvan Gurusamy; Marc T. Avey; Joshua Montroy; Marilena Loizidou; Irfan Ahmed; David Moher; Jan Vollert; Manoj M. Lalu

Venue: PeerJ

Type: Publication

Abstract: BackgroundOnly a small proportion of preclinical research (research performed in animal models prior to clinical trials in humans) translates into clinical benefit in humans. Possible reasons for the lack of translation of the results observed in preclinical research into human clinical benefit include the design, conduct, and reporting of preclinical studies. There is currently no formal domain-based assessment of the clinical relevance of preclinical research. To address this issue, we have developed a tool for the assessment of the clinical ... (read more)

Topics: Medical physics

DOI: 10.7717/peerj.10673

BIP! social metrics: 0 30
External links: Crossref OpenAIRE

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