BIP! Finder - At Embryo Implantation Site IL-35 Secreted by Trophoblast, Polarizing T Cells towards IL-35+ IL-10+ IL-4+ Th2-Type Cells, Could Favour Fetal Allograft Tolerance and Pregnancy Success

2022 • At Embryo Implantation Site IL-35 Secreted by Trophoblast, Polarizing T Cells towards IL-35+ IL-10+ IL-4+ Th2-Type Cells, Could Favour Fetal Allograft Tolerance and Pregnancy Success

Authors: Letizia Lombardelli; Federica Logiodice; Ornela Kullolli; Herman Haller; Chiara Agostinis; Roberta Bulla; Daniel Rukavina; Marie-Pierre Piccinni

Venue: International Journal of Molecular Sciences

Type: Publication

Abstract: We investigated the role of rhIL-35, at low concentrations compatible with those produced by human trophoblast cells (less than 1 ng/mL), on human T helper (Th) cell functions and the presence of decidual IL-35-producing Th cells in human pregnancy. We found that human trophoblast cells produced IL-35 but not IL-4 or IL-10. RhIL-35, at concentrations produced by human trophoblasts, polarized T cells towards IL-35+, IL-10+, IL-4+ Th2-type cells and to Foxp3+ EBI3+ p35+ T reg cells producing IL-35 but not IL-10 and IL-4. Moreover, rhIL-35 at low ... (read more)

Impact:

3.3224097E-9 2.7887241E-9 1 1

/ Attention: 0 3

Topics: Cell biology Immunology Andrology

DOI: 10.3390/ijms23094926

External links: Crossref OpenAIRE

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