BIP! Finder - PD-1 Blockade Aggravates Epstein–Barr Virus+ Post-Transplant Lymphoproliferative Disorder in Humanized Mice Resulting in Central Nervous System Involvement and CD4+ T Cell Dysregulations

2021 • PD-1 Blockade Aggravates Epstein–Barr Virus+ Post-Transplant Lymphoproliferative Disorder in Humanized Mice Resulting in Central Nervous System Involvement and CD4+ T Cell Dysregulations

Authors: Valery Volk; Sebastian J. Theobald; Simon Danisch; Sahamoddin Khailaie; Maja Kalbarczyk; Andreas Schneider; Julia Bialek-Waldmann; Nicole Krönke; Yun Deng; Britta Eiz-Vesper; Anna Christina Dragon; Constantin von Kaisenberg; Stefan Lienenklaus; Andre Bleich; James Keck; Michael Meyer-Hermann; Frank Klawonn; Wolfgang Hammerschmidt; Henri-Jacques Delecluse; Christian Münz; Friedrich Feuerhake; Renata Stripecke

Venue: Frontiers in Oncology

Type: Publication

Abstract: Post-transplant lymphoproliferative disorder (PTLD) is one of the most common malignancies after solid organ or allogeneic stem cell transplantation. Most PTLD cases are B cell neoplasias carrying Epstein-Barr virus (EBV). A therapeutic approach is reduction of immunosuppression to allow T cells to develop and combat EBV. If this is not effective, approaches include immunotherapies such as monoclonal antibodies targeting CD20 and adoptive T cells. Immune checkpoint inhibition (ICI) to treat EBV+ PTLD was not established clinically due to the ri... (read more)

Impact:

2.5853163E-8 3.4454462E-9 24 24

/ Attention: 0 21

Topics: Immunology Cancer research

DOI: 10.3389/fonc.2020.614876

External links: Crossref OpenAIRE

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