Authors: Valery Volk, Sebastian J. Theobald, Simon Danisch, Sahamoddin Khailaie, Maja Kalbarczyk, Andreas Schneider, Julia Bialek-Waldmann, Nicole Krönke, Yun Deng, Britta Eiz-Vesper, Anna Christina Dragon, Constantin von Kaisenberg, Stefan Lienenklaus, Andre Bleich, James Keck, Michael Meyer-Hermann, Frank Klawonn, Wolfgang Hammerschmidt, Henri-Jacques Delecluse, Christian Münz, Friedrich Feuerhake, Renata Stripecke
Venue: Frontiers in Oncology
Type: Publication
Abstract: Post-transplant lymphoproliferative disorder (PTLD) is one of the most common malignancies after solid organ or allogeneic stem cell transplantation. Most PTLD cases are B cell neoplasias carrying Epstein-Barr virus (EBV). A therapeutic approach is reduction of immunosuppression to allow T cells to develop and combat EBV. If this is not effective, approaches include immunotherapies such as monoclonal antibodies targeting CD20 and adoptive T cells. Immune checkpoint inhibition (ICI) to treat EBV+ PTLD was not established clinically due to the ri...
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Topics: 
Immunology
Cancer research
DOI:
10.3389/fonc.2020.614876
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