BIP! Finder - Insulin-Like Growth Factor Binding Protein 2 Is Associated With Biomarkers of Alzheimer’s Disease Pathology and Shows Differential Expression in Transgenic Mice

2018 • Insulin-Like Growth Factor Binding Protein 2 Is Associated With Biomarkers of Alzheimer’s Disease Pathology and Shows Differential Expression in Transgenic Mice

Authors: Luke W. Bonham; Ethan G. Geier; Natasha Z. R. Steele; Dominic Holland; Bruce L. Miller; Anders M. Dale; Rahul S. Desikan; Jennifer S. Yokoyama; Alzheimer’s Disease Neuroimaging Initiative

Venue: Frontiers in Neuroscience

Type: Publication

Abstract: There is increasing evidence that metabolic dysfunction plays an important role in Alzheimer's disease (AD). Brain insulin resistance and subsequent impairment of insulin and insulin-like growth factor (IGF) signaling are associated with the neurodegenerative and clinical features of AD. Nevertheless, how the brain insulin/IGF signaling system is altered in AD and the effects of these changes on AD pathobiology are not well understood. IGF binding protein 2 (IGFBP-2) is an abundant cerebral IGF signaling protein and there is early evidence sugg... (read more)

Impact:

2.7975805E-8 3.6703525E-9 37 14

/ Attention: 0 24

Topics: Pathology Neuroscience

DOI: 10.3389/fnins.2018.00476

External links: Crossref OpenAIRE

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