BIP! Finder - Antiviral Activity of Interferon Alpha-Inducible Protein 27 Against Hepatitis B Virus Gene Expression and Replication

2021 • Antiviral Activity of Interferon Alpha-Inducible Protein 27 Against Hepatitis B Virus Gene Expression and Replication

Authors: Hafiz Ullah, Muhammad Sajid, Kun Yan, Jiangpeng Feng, Miao He, Muhammad Adnan Shereen, Qiaohong Li, Tianmo Xu, Ruidong Hao, Deyin Guo, Yu Chen, Limin Zhou, Li Zhou

Venue: Frontiers in Microbiology

Type: Article

Abstract: Despite the availability of effective vaccines, hepatitis B virus (HBV) is still a major health issue, and approximately 350 million people have been chronically infected with HBV throughout the world. Interferons (IFNs) are the key molecules in the innate immune response that restrict several kinds of viral infections via the induction of hundreds of IFN-stimulated genes (ISGs). The objective of this study was to confirm if interferon alpha-inducible protein 27 (IFI27) as an ISG could inhibit HBV gene expression and DNA replication both in cel... (read more)

Topics: Virology Genetics

DOI: 10.3389/fmicb.2021.656353

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External links: Crossref , OpenAIRE

References (56) Citations (9) BibTex PDF

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