BIP! Finder - Phase II study of central nervous system (CNS)-directed chemotherapy including high-dose chemotherapy with autologous stem cell transplantation for CNS relapse of aggressive lymphomas

2012 • Phase II study of central nervous system (CNS)-directed chemotherapy including high-dose chemotherapy with autologous stem cell transplantation for CNS relapse of aggressive lymphomas

Authors: Korfel, Agnieszka, Elter, Thomas, Thiel, Eckhard, Hänel, Matthias, Möhle, Robert, Schroers, Roland, Reiser, Marcel, Dreyling, Martin, Eucker, Jan, Scholz, Christian, Metzner, Bernd, Röth, Alexander, Birkmann, Josef, Schlegel, Uwe, Martus, Peter, Illerhaus, Gerard, Fischer, Lars

Venue: Haematologica

Type: Publication

Abstract: The prognosis of patients with central nervous system relapse of aggressive lymphoma is very poor with no therapy established so far. In a prospective multicenter phase II study, we evaluated a potentially curative chemotherapy-only regimen in these patients. Adult immunocompetent patients 65 years of age or under received induction chemotherapy with MTX/IFO/DEP (methotrexate 4 g/m(2) intravenously (i.v.) Day 1, ifosfamide 2 g/m(2) i.v. Days 3- 5 and liposomal cytarabine 50 mg intrathecally (i.th) Day 6) and AraC/TT/DEP (cytarabine 3g/m(2) i.v.... (read more)

Topics: Internal medicine Gastroenterology Surgery

DOI: 10.3324/haematol.2012.077917

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