BIP! Finder - Daratumumab plus bortezomib and dexamethasone versus bortezomib and dexamethasone in relapsed or refractory multiple myeloma: updated analysis of CASTOR

2018 • Daratumumab plus bortezomib and dexamethasone versus bortezomib and dexamethasone in relapsed or refractory multiple myeloma: updated analysis of CASTOR

Authors: Spencer, Andrew; Lentzsch, Suzanne; Weisel, Katja; Avet-Loiseau, Hervé; Mark, Tomer M; Spicka, Ivan; Masszi, Tamas; Lauri, Birgitta; Levin, Mark-David; Bosi, Alberto; Hungria, Vania; Cavo, Michele; Lee, Je-Jung; Nooka, Ajay K; Quach, Hang; Lee, Cindy; Barreto, Wolney; Corradini, Paolo; Min, Chang-Ki; Scott, Emma C; Chanan-Khan, Asher A; Horvath, Noemi; Capra, Marcelo; Beksac, Meral; Ovilla, Roberto; Jo, Jae-Cheol; Shin, Ho-Jin; Sonneveld, Pieter; Soong, David; Casneuf, Tineke; Chiu, Christopher; Amin, Himal; Qi, Ming; Thiyagarajah, Piruntha; Sasser, A Kate; Schecter, Jordan M; Mateos, Maria-Victoria

Venue: Haematologica

Type: Publication

Abstract: Daratumumab, a CD38 human monoclonal antibody, demonstrated significant clinical activity in combination with bortezomib and dexamethasone versus bortezomib and dexamethasone alone in the primary analysis of CASTOR, a phase 3 study in relapsed and/or refractory multiple myeloma. A post hoc analysis based on treatment history and longer follow up is presented. After 19.4 (range: 0-27.7) months of median follow up, daratumumab plus bortezomib and dexamethasone prolonged progression-free survival (median: 16.7 versus 7.1 months; hazard ratio, 0.31... (read more)

Topics: Internal medicine Oncology

DOI: 10.3324/haematol.2018.194118

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External links: Crossref OpenAIRE

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