BIP! Finder - Modification of cell-surface thiols elicits activation of human monocytic cell line THP-1: Possible involvement in effect of haptens 2,4-dinitrochlorobenzene and nickel sulfate

2009 • Modification of cell-surface thiols elicits activation of human monocytic cell line THP-1: Possible involvement in effect of haptens 2,4-dinitrochlorobenzene and nickel sulfate

Authors: Morihiko, Hirota, Mie, Suzuki, Shigenobu, Hagino, Saori, Kagatani, Yoshinori, Sasaki, Setsuya, Aiba, Hiroshi, Itagaki

Venue: The Journal of Toxicological Sciences

Type: Publication

Abstract: Human monocytic cell line THP-1 cells are used as an indicator for in vitro skin sensitization testing. Although p38 mitogen-activated protein kinases (MAPKs) and intracellular redox imbalance play crucial roles in the activation of THP-1 by skin sensitizers, the trigger of cell activation has not been identified. Therefore, we examined whether haptens induce THP-1 maturation directly or indirectly. 2,4-Dinitrochlorobenzene (DNCB), but not dinitrophenol (DNP)-conjugated bovine serum albumin or DNP-conjugated fetal bovine serum, induced CD86 exp... (read more)

Topics: Cell biology Biochemistry

DOI: 10.2131/jts.34.139

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