Authors: Nora Franceschini; Claudia Giambartolomei; Paul S. de Vries; Chris Finan; Joshua C. Bis; Rachael P. Huntley; Ruth C. Lovering; Salman M. Tajuddin; Thomas W. Winkler; Misa Graff; Maryam Kavousi; Caroline Dale; Albert V. Smith; Edith Hofer; Elisabeth M. van Leeuwen; Ilja M. Nolte; Lingyi Lu; Markus Scholz; Muralidharan Sargurupremraj; Niina Pitkänen; Oscar Franzén; Peter K. Joshi; Raymond Noordam; Riccardo E. Marioni; Shih-Jen Hwang; Solomon K. Musani; Ulf Schminke; Walter Palmas; Aaron Isaacs; Adolfo Correa; Alan B. Zonderman; Albert Hofman; Alexander Teumer; Amanda J. Cox; André G. Uitterlinden; Andrew Wong; Andries J. Smit; Anne B. Newman; Annie Britton; Arno Ruusalepp; Bengt Sennblad; Bo Hedblad; Bogdan Pasaniuc; Brenda W. Penninx; Carl D. Langefeld; Christina L. Wassel; Christophe Tzourio; Cristiano Fava; Damiano Baldassarre; Daniel H. O’Leary; Daniel Teupser; Diana Kuh; Elena Tremoli; Elmo Mannarino; Enzo Grossi; Eric Boerwinkle; Eric E. Schadt; Erik Ingelsson; Fabrizio Veglia; Fernando Rivadeneira; Frank Beutner; Ganesh Chauhan; Gerardo Heiss; Harold Snieder; Harry Campbell; Henry Völzke; Hugh S. Markus; Ian J. Deary; J. Wouter Jukema; Jacqueline de Graaf; Jacqueline Price; Janne Pott; Jemma C. Hopewell; Jingjing Liang; Joachim Thiery; Jorgen Engmann; Karl Gertow; Kenneth Rice; Kent D. Taylor; Klodian Dhana; Lambertus A. L. M. Kiemeney; Lars Lind; Laura M. Raffield; Lenore J. Launer; Lesca M. Holdt; Marcus Dörr; Martin Dichgans; Matthew Traylor; Matthias Sitzer; Meena Kumari; Mika Kivimaki; Mike A. Nalls; Olle Melander; Olli Raitakari; Oscar H. Franco; Oscar L. Rueda-Ochoa; Panos Roussos; Peter H. Whincup; Philippe Amouyel; Philippe Giral; Pramod Anugu; Quenna Wong; Rainer Malik; Rainer Rauramaa; Ralph Burkhardt; Rebecca Hardy; Reinhold Schmidt; Renée de Mutsert; Richard W. Morris; Rona J. Strawbridge; S. Goya Wannamethee; Sara Hägg; Sonia Shah; Stela McLachlan; Stella Trompet; Sudha Seshadri; Sudhir Kurl; Susan R. Heckbert; Susan Ring; Tamara B. Harris; Terho Lehtimäki; Tessel E. Galesloot; Tina Shah; Ulf de Faire; Vincent Plagnol; Wayne D. Rosamond; Wendy Post; Xiaofeng Zhu; Xiaoling Zhang; Xiuqing Guo; Yasaman Saba; Yukinori Okada; Aniket Mishra; Loes Rutten-Jacobs; Anne-Katrin Giese; Sander W. van der Laan; Solveig Gretarsdottir; Christopher D. Anderson; Michael Chong; Hieab H. H. Adams; Tetsuro Ago; Peter Almgren; Hakan Ay; Traci M. Bartz; Oscar R. Benavente; Steve Bevan; Giorgio B. Boncoraglio; Robert D. Brown; Adam S. Butterworth; Caty Carrera; Cara L. Carty; Daniel I. Chasman; Wei-Min Chen; John W. Cole; Ioana Cotlarciuc; Carlos Cruchaga; John Danesh; Paul I. W. de Bakker; Anita L. DeStefano; Marcel den Hoed; Qing Duan; Stefan T. Engelter; Guido J. Falcone; Rebecca F. Gottesman; Raji P. Grewal; Stefan Gustafsson; Jeffrey Haessler; Ahamad Hassan; Aki S. Havulinna; Elizabeth G. Holliday; George Howard; Fang-Chi Hsu; Hyacinth I. Hyacinth; M. Arfan Ikram; Marguerite R. Irvin; Xueqiu Jian; Jordi Jiménez-Conde; Julie A. Johnson; Masahiro Kanai; Keith L. Keene; Brett M. Kissela; Dawn O. Kleindorfer; Charles Kooperberg; Michiaki Kubo; Leslie Lange; Claudia Langenberg; Jin-Moo Lee; Robin Lemmens; Didier Leys; Cathryn M. Lewis; Wei-Yu Lin; Arne G. Lindgren; Erik Lorentzen; Patrik K. Magnusson; Jane Maguire; Ani Manichaikul; Patrick F. McArdle; James F. Meschia; Thomas H. Mosley; Toshiharu Ninomiya; Martin J. O’Donnell; Sara L. Pulit; Kristiina Rannikmäe; Alexander P. Reiner; Kathryn M. Rexrode; Stephen S. Rich; Paul M. Ridker; Natalia S. Rost; Peter M. Rothwell; Tatjana Rundek; Ralph L. Sacco; Saori Sakaue; Michele M. Sale; Veikko Salomaa; Bishwa R. Sapkota; Carsten O. Schmidt; Pankaj Sharma; Agnieszka Slowik; Cathie L. M. Sudlow; Christian Tanislav; Turgut Tatlisumak; Vincent N. S. Thijs; Gudmar Thorleifsson; Unnur Thorsteinsdottir; Steffen Tiedt; Matthew Walters; Nicholas J. Wareham; Sylvia Wassertheil-Smoller; Kerri L. Wiggins; Qiong Yang; Salim Yusuf; Tomi Pastinen; Simon Koplev; Veronica Codoni; Mete Civelek; Nick Smith; David A. Trégouët; Ingrid E. Christophersen; Carolina Roselli; Steven A. Lubitz; Patrick T. Ellinor; E. Shyong Tai; Jaspal S. Kooner; Norihiro Kato; Jiang He; Pim van der Harst; Paul Elliott; John C. Chambers; Fumihiko Takeuchi; Andrew D. Johnson; Dharambir K. Sanghera; Christina Jern; Daniel Strbian; Israel Fernandez-Cadenas; W. T. Longstreth; Arndt Rolfs; Jun Hata; Daniel Woo; Jonathan Rosand; Guillaume Pare; Danish Saleheen; Kari Stefansson; Bradford B. Worrall; Steven J. Kittner; Joanna M. M. Howson; Yoichiro Kamatani; Abbas Dehghan; Adrie Seldenrijk; Alanna C. Morrison; Anders Hamsten; Bruce M. Psaty; Cornelia M. van Duijn; Deborah A. Lawlor; Dennis O. Mook-Kanamori; Donald W. Bowden; Helena Schmidt; James F. Wilson; James G. Wilson; Jerome I. Rotter; Joanna M. Wardlaw; John Deanfield; Julian Halcox; Leo-Pekka Lyytikäinen; Markus Loeffler; Michele K. Evans; Stéphanie Debette; Steve E. Humphries; Uwe Völker; Vilmundur Gudnason; Aroon D. Hingorani; Johan L. M. Björkegren; Juan P. Casas; Christopher J. O’Donnell

Venue: Nature Communications

Type: Publication

Abstract: AbstractCarotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,128 individuals for cIMT, and 48,434 individuals for carotid plaque traits. We identify eight novel susceptibility loci for cIMT, one independent association at the previously-identified PINX1 locus, and one novel locus for carotid plaque. Colocalization analysis with nearby vascular ex... (read more)

DOI: 10.17863/cam.34589