Abstract: Here we demonstrate that not only is hippocampal neurogenesis persistent through the tenth decade of life, but it is detectable even in patients with mild cognitive impairments and Alzheimer’s disease. In a cohort of 18 patients with a mean age of 90.6 years, Nestin+Sox2+Ki67+ neural stem cells and DCX+ neuroblasts and immature neurons were detected, but their number greatly varies between patients. Nestin+ cells localize in the anterior hippocampus while neural progenitor cells, neuroblasts and immature neurons are evenly distributed along t...
(read more)