BIP! Finder - Inhibition of IRGM establishes a robust antiviral immune state to restrict pathogenic viruses

2021 • Inhibition of IRGM establishes a robust antiviral immune state to restrict pathogenic viruses

Authors: Nath, Parej; Chauhan, Nishant Ranjan; Jena, Kautilya Kumar; Datey, Ankita; Kumar, Nilima Dinesh; Mehto, Subhash; De, Saikat; Nayak, Tapas Kumar; Priyadarsini, Swatismita; Rout, Kshitish; Bal, Ramyasingh; Murmu, Krushna C; Kalia, Manjula; Patnaik, Srinivas; Prasad, Punit; Reggiori, Fulvio; Chattopadhyay, Soma; Chauhan, Santosh

Venue: EMBO reports

Type: Publication

Abstract: The type I interferon (IFN) response is the major host arsenal against invading viruses. IRGM is a negative regulator of IFN responses under basal conditions. However, the role of human IRGM during viral infection has remained unclear. In this study, we show that IRGM expression is increased upon viral infection. IFN responses induced by viral PAMPs are negatively regulated by IRGM. Conversely, IRGM depletion results in a robust induction of key viral restriction factors including IFITMs, APOBECs, SAMHD1, tetherin, viperin, and HERC5/6. Additio... (read more)

Impact:

2.0715447E-8 3.243172E-9 21 19

/ Attention: 0 16

Topics: Virology

DOI: 10.15252/embr.202152948

External links: Crossref OpenAIRE

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