BIP! Finder - A Salmonella Small Non-Coding RNA Facilitates Bacterial Invasion and Intracellular Replication by Modulating the Expression of Virulence Factors

2011 • A Salmonella Small Non-Coding RNA Facilitates Bacterial Invasion and Intracellular Replication by Modulating the Expression of Virulence Factors

Authors: Ruobin Wu; Yong-Ping Bai; Edward Yang; Elton Chan; Fenyong Liu; Gia-Phong Vu; Hao Gong; Sangwei Lu

Venue: PLoS Pathogens

Type: Publication

Abstract: Small non-coding RNAs (sRNAs) that act as regulators of gene expression have been identified in all kingdoms of life, including microRNA (miRNA) and small interfering RNA (siRNA) in eukaryotic cells. Numerous sRNAs identified in Salmonella are encoded by genes located at Salmonella pathogenicity islands (SPIs) that are commonly found in pathogenic strains. Whether these sRNAs are important for Salmonella pathogenesis and virulence in animals has not been reported. In this study, we provide the first direct evidence that a pathogenicity island-e... (read more)

Impact:

2.5512191E-8 5.3460667E-9 96 22

/ Attention: 0 34

Topics: Microbiology Genetics

DOI: 10.1371/journal.ppat.1002120

External links: Crossref OpenAIRE

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