BIP! Finder - The Interferon Response Inhibits HIV Particle Production by Induction of TRIM22

2008 • The Interferon Response Inhibits HIV Particle Production by Induction of TRIM22

Authors: Stephen D. Barr; Frederic D. Bushman; James R. Smiley

Venue: PLoS Pathogens

Type: Publication

Abstract: Treatment of human cells with Type 1 interferons restricts HIV replication. Here we report that the tripartite motif protein TRIM22 is a key mediator. We used transcriptional profiling to identify cellular genes that were induced by interferon treatment and identified TRIM22 as one of the most strongly up-regulated genes. We confirmed, as in previous studies, that TRIM22 over-expression inhibited HIV replication. To assess the role of TRIM22 expressed under natural inducing conditions, we compared the effects of interferon in cells depleted for... (read more)

Impact:

5.491965E-8 1.1015173E-8 241 56

/ Attention: 0 36

Topics: Virology

DOI: 10.1371/journal.ppat.1000007

External links: Crossref OpenAIRE

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