BIP! Finder - Induction of high tolerance to artemisinin by sub-lethal administration: A new in vitro model of P. falciparum

2018 • Induction of high tolerance to artemisinin by sub-lethal administration: A new in vitro model of P. falciparum

Authors: De Lucia, Serena; Tsamesidis, Ioannis; Pau, Maria Carmina; Kesely, Kristina R; Pantaleo, Antonella; TURRINI, FRANCESCO

Venue: PLOS ONE

Type: Publication

Abstract: Artemisinin resistance is a major threat to malaria control efforts. Resistance is characterized by an increase in the Plasmodium falciparum parasite clearance half-life following treatment with artemisinin-based combination therapies (ACTs) and an increase in the percentage of surviving parasites. The remarkably short blood half-life of artemisinin derivatives may contribute to drug-resistance, possibly through factors including sub-lethal plasma concentrations and inadequate exposure. Here we selected for a new strain of artemisinin resistant... (read more)

Impact:

1.36173215E-8 3.227124E-9 18 10

/ Attention: 0 82

Topics: Pharmacology

DOI: 10.1371/journal.pone.0191084

External links: Crossref OpenAIRE

BibTex PDF

Topic-specific impact indicators

Popularity:
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Influence:
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citation Count:
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Impulse:
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.