BIP! Finder - Induction of high tolerance to artemisinin by sub-lethal administration: A new in vitro model of P. falciparum

2018 • Induction of high tolerance to artemisinin by sub-lethal administration: A new in vitro model of P. falciparum

Authors: De Lucia, Serena; Tsamesidis, Ioannis; Pau, Maria Carmina; Kesely, Kristina R; Pantaleo, Antonella; TURRINI, FRANCESCO

Venue: PLOS ONE

Type: Publication

Abstract: Artemisinin resistance is a major threat to malaria control efforts. Resistance is characterized by an increase in the Plasmodium falciparum parasite clearance half-life following treatment with artemisinin-based combination therapies (ACTs) and an increase in the percentage of surviving parasites. The remarkably short blood half-life of artemisinin derivatives may contribute to drug-resistance, possibly through factors including sub-lethal plasma concentrations and inadequate exposure. Here we selected for a new strain of artemisinin resistant... (read more)

Impact:

1.36173215E-8 3.227124E-9 18 10

/ Attention: 0 83

Topics: Pharmacology

DOI: 10.1371/journal.pone.0191084

External links: Crossref OpenAIRE

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