BIP! Finder - Phage endolysins are adapted to specific hosts and are evolutionarily dynamic

2022 • Phage endolysins are adapted to specific hosts and are evolutionarily dynamic

Authors: Frank Oechslin; Xiaojun Zhu; Moira B. Dion; Rong Shi; Sylvain Moineau

Venue: PLOS Biology

Type: Publication

Abstract: Endolysins are produced by (bacterio)phages to rapidly degrade the bacterial cell wall and release new viral particles. Despite sharing a common function, endolysins present in phages that infect a specific bacterial species can be highly diverse and vary in types, number, and organization of their catalytic and cell wall binding domains. While much is now known about the biochemistry of phage endolysins, far less is known about the implication of their diversity on phage–host adaptation and evolution. Using CRISPR-Cas9 genome editing, we cou... (read more)

Topics: Genetics

DOI: 10.1371/journal.pbio.3001740

BIP! social metrics: 0 15
External links: Crossref OpenAIRE

Related works: Dataset 1

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