BIP! Finder - Important Aspects concerning the Quantification of Biomolecules by Time-of-Flight Secondary-Ion Mass Spectrometry

1996 • Important Aspects concerning the Quantification of Biomolecules by Time-of-Flight Secondary-Ion Mass Spectrometry

Authors: Anthony J. Nicola; Andrew Proctor; David M. Hercules; David C. Muddiman

Venue: Applied Spectroscopy

Type: Publication

Abstract: Fundamental aspects regarding the use of time-of-flight secondary-ion mass spectrometry (TOF-SIMS) as a quantitative tool for the analysis of organic compounds are reported. The following factors are discussed: (1) the use of Poisson's law to correct for dead-time in single-ion data collection; (2) practical considerations concerning the analysis of “real world” samples; and (3) the effect of the etching process on the reproducibility of the intensity ratio (analyte/internal standard) of Ag-cationized species. To evaluate the importance of ... (read more)

Impact:

1.1234078E-9 4.1302375E-9 9 3

/ Attention: 0 19

Topics: Chromatography

DOI: 10.1366/0003702963906410

External links: Crossref OpenAIRE

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