BIP! Finder - KEYNOTE-365 cohort B: Pembrolizumab (pembro) plus docetaxel and prednisone in abiraterone (abi) or enzalutamide (enza)–pretreated patients with metastatic castration-resistant prostate cancer (mCRPC)—New data after an additional 1 year of follow-up.

2021 • KEYNOTE-365 cohort B: Pembrolizumab (pembro) plus docetaxel and prednisone in abiraterone (abi) or enzalutamide (enza)–pretreated patients with metastatic castration-resistant prostate cancer (mCRPC)—New data after an additional 1 year of follow-up.

Authors: Emanuela Romano; Margitta Retz; Evan Y. Yu; Martin Boegemann; Xin Tong Li; Johann S. de Bono; Gwenaelle Gravis; Josep M. Piulats; Howard Gurney; Anthony M. Joshua; William R. Berry; Charles Schloss; Christian Heinrich Poehlein; Christophe Massard; Michael Paul Kolinsky; Loic Mourey; Henry Jacob Conter; Leonard Joseph Appleman; Srikala S. Sridhar; Urban Emmenegger

Venue: Journal of Clinical Oncology

Type: Publication

Abstract: 10 Background: For men with mCRPC, systemic therapies such as docetaxel and cabazitaxel improve survival, but more effective treatments are needed. KEYNOTE-365 (NCT02861573) is a phase 1b/2 study to examine the safety and efficacy of pembro in combination with 4 different study medications (cohorts A, B, C, D) in mCRPC. Previous data from cohort B with a median of 20 months of follow-up showed that pembro + docetaxel and prednisone was well tolerated and had antitumor activity in patients (pts) with mCRPC previously treated with abi or enza. Ne... (read more)

Topics: Internal medicine Oncology

DOI: 10.1200/jco.2021.39.6_suppl.10

BIP! social metrics: 0 8
External links: Crossref OpenAIRE

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