BIP! Finder - The methylome of Biomphalaria glabrata and other mollusks: enduring modification of epigenetic landscape and phenotypic traits by a new DNA methylation inhibitor

2020 • The methylome of Biomphalaria glabrata and other mollusks: enduring modification of epigenetic landscape and phenotypic traits by a new DNA methylation inhibitor

Authors: Christoph Grunau; Fleur Gawehns; Slavica Ivanovic; Patrice David; Paola B. Arimondo; Koen J. F. Verhoeven; Nelia Luviano; Marie Lopez; Cristian Chaparro; Céline Cosseau

Venue: Epigenetics & Chromatin

Type: Publication

Abstract: Abstract Background 5-Methylcytosine (5mC) is an important epigenetic mark in eukaryotes. Little information about its role exists for invertebrates. To investigate the contribution of 5mC to phenotypic variation in invertebrates, alteration of methylation patterns needs to be produced. Here, we apply new non-nucleoside DNA methyltransferase inhibitors (DNMTi) to introduce aleatory changes into the methylome of mollusk species. Results Flavanone inhibitor Flv1 was efficient in reducing 5mC in the freshwater snails Biomphalaria glabrata and Phys... (read more)

Impact:

1.0614446E-8 3.0630425E-9 9 8

/ Attention: 0 17

Topics: Genetics Evolutionary biology

DOI: 10.1186/s13072-021-00422-7

External links: Crossref OpenAIRE

Related works: Dataset 2

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