BIP! Finder - Mesenchymal adenomatous polyposis coli plays critical and diverse roles in regulating lung development

2015 • Mesenchymal adenomatous polyposis coli plays critical and diverse roles in regulating lung development

Authors: Gianluca Turcatel; Wei Shi; Bang-Ping Qian; Hui Chen; Douglas B. Menke; David Warburton; Saverio Bellusci; Joanne Chiu; Elie El Agha; Yongfeng Luo

Venue: BMC Biology

Type: Publication

Abstract: Adenomatous polyposis coli (Apc) is a tumor suppressor that inhibits Wnt/Ctnnb1. Mutations of Apc will not only lead to familial adenomatous polyposis with associated epithelial lesions, but will also cause aggressive fibromatosis in mesenchymal cells. However, the roles of Apc in regulating mesenchymal cell biology and organogenesis during development are unknown.We have specifically deleted the Apc gene in lung mesenchymal cells during early lung development in mice. Loss of Apc function resulted in immediate mesenchymal cell hyperproliferati... (read more)

Impact:

5.49675E-9 3.1987122E-9 14 7

/ Attention: 0 36

Topics: Cancer research Cell biology Immunology

DOI: 10.1186/s12915-015-0153-1

External links: Crossref OpenAIRE

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