BIP! Finder - Comparison of nuisance parameters in pediatric versus adult randomized trials: a meta-epidemiologic empirical evaluation

2018 • Comparison of nuisance parameters in pediatric versus adult randomized trials: a meta-epidemiologic empirical evaluation

Authors: Ingeborg van der Tweel; Susan S. Ellenberg; Lisa M. Askie; Ben Vandermeer; Dirk Bassler; Johanna H. van der Lee; Stephanie S. Weinreich; Ricardo M. Fernandes; Despina G. Contopoulos-Ioannidis; Marijke C. Jansen-van der Weide; Paola Baiardi; Haroon Saloojee

Venue: BMC Medical Research Methodology

Type: Publication

Abstract: We wished to compare the nuisance parameters of pediatric vs. adult randomized-trials (RCTs) and determine if the latter can be used in sample size computations of the former.In this meta-epidemiologic empirical evaluation we examined meta-analyses from the Cochrane Database of Systematic-Reviews, with at least one pediatric-RCT and at least one adult-RCT. Within each meta-analysis of binary efficacy-outcomes, we calculated the pooled-control-group event-rate (CER) across separately all pediatric and adult-trials, using random-effect models and... (read more)

Topics: Pediatrics Internal medicine

DOI: 10.1186/s12874-017-0456-8

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External links: Crossref OpenAIRE

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