BIP! Finder - An Exploratory Study of Two Caco-2 Cell Models for Oral Absorption: A Report on Their Within-laboratory and Between-laboratory Variability, and Their Predictive Capacity

2010 • An Exploratory Study of Two Caco-2 Cell Models for Oral Absorption: A Report on Their Within-laboratory and Between-laboratory Variability, and Their Predictive Capacity

Authors: Pilar, Prieto, Sebastian, Hoffmann, Valentina, Tirelli, Francesco, Tancredi, Isabel, González, Marival, Bermejo, Isabella, De Angelis

Venue: Alternatives to Laboratory Animals

Type: Publication

Abstract: In 2005, the European Centre for the Validation of Alternative Methods (ECVAM) sponsored a study aimed at evaluating the reproducibility (between-laboratory and within-laboratory variability) and the predictive capacity of two in vitro cellular systems — the Caco-2/ATCC parental cell line and the Caco-2/TC7 clone — for estimating the oral fraction absorbed (Fa) in humans. Two laboratories, both of which had experience with Caco-2 cultures, participated in the study. Ten test chemicals with documented in vivo oral absorption data were select... (read more)

Topics: Chromatography

DOI: 10.1177/026119291003800510

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External links: Crossref OpenAIRE

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