BIP! Finder - p44 Mitogen-Activated Protein Kinase (Extracellular Signal-Regulated Kinase 1)–Dependent Signaling Contributes to Epithelial Skin Carcinogenesis

2006 • p44 Mitogen-Activated Protein Kinase (Extracellular Signal-Regulated Kinase 1)–Dependent Signaling Contributes to Epithelial Skin Carcinogenesis

Authors: Christine Bourcier, Arnaud Jacquel, Jochen Hess, Isabelle Peyrottes, Peter Angel, Paul Hofman, Patrick Auberger, Jacques Pouysségur, Gilles Pagès

Venue: Cancer Research

Type: Publication

Abstract: Abstract Extracellular signal-regulated kinases (ERK) regulate cellular functions in response to a variety of external signals. However, the specific functions of individual ERK isoforms are largely unknown. Hence, we have investigated the specific function of ERK1 in skin homeostasis and tumorigenesis in ERK1 knockout mice. They spontaneously develop cutaneous lesions and hyperkeratosis with epidermis thickness. Skin hyperproliferation and inflammation induced by application of 12-O-tetradecanoylphorbol-13-acetate (TPA) is strongly reduced in ... (read more)

Topics: Cell biology Cancer research

DOI: 10.1158/0008-5472.can-05-3129

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External links: Crossref OpenAIRE

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