Authors: Simon Rothwell, Hector Chinoy, Janine A. Lamb, Frederick W. Miller, Lisa G. Rider, Lucy R. Wedderburn, Neil McHugh, Andrew L. Mammen, Zoe E Betteridge, Sarah L Tansley, John Bowes, Jiří Vencovský, Claire T Deakin, Katalin Dankó, Limaye Vidya, Albert Selva-O'Callaghan, Lauren M. Pachman, Ann M. Reed, Øyvind Molberg, Olivier Benveniste, Pernille Mathiesen, Timothy R D J Radstake, Andrea Doria, Jan De Bleecker, Annette Lee, Michael G. Hanna, Pedro Machado, William E R Ollier, Peter K. Gregersen, Leonid Padyukov, Terrance P. O'Hanlon, Robert G. Cooper, Ingrid E. Lundberg
Venue: Annals of the Rheumatic Diseases
Type: Publication
Abstract: ObjectivesIdiopathic inflammatory myopathies (IIM) are a spectrum of rare autoimmune diseases characterised clinically by muscle weakness and heterogeneous systemic organ involvement. The strongest genetic risk is within the major histocompatibility complex (MHC). Since autoantibody presence defines specific clinical subgroups of IIM, we aimed to correlate serotype and genotype, to identify novel risk variants in the MHC region that co-occur with IIM autoantibodies.MethodsWe collected available autoantibody data in our cohort of 2582 Caucasian ...
(read more)
Loading (it may take a couple of seconds)...
Loading (it may take a couple of seconds)...