Authors: Hurst, Emma A; Mellanby, Richard J; Handel, Ian; Griffith, David M; Rossi, Adriano G; Walsh, Timothy S; Shankar-Hari, Manu; Dunning, Jake; Homer, Natalie Z; Denham, Scott G; Devine, Kerri; Holloway, Paul A; Moore, Shona C; Thwaites, Ryan S; Samanta, Romit J; Hardwick, Hayley E; Oosthuyzen, Wilna; Turtle, Lance; Semple, Malcolm G; Openshaw, Peter J M; Baillie, J Kenneth; ISARIC4C Investigators; Kenneth Baillie, J; Carson, Gail; Alex, Beatrice; Bach, Benjamin; Barclay, Wendy S; Bogaert, Debby; Chand, Meera; Cooke, Graham S; Docherty, Annemarie B; Filipe, Ana Da Silva; Fletcher, Tom; Green, Christopher A; Harrison, Ewen M; Hiscox, Julian A; Horby, Peter W; Ijaz, Samreen; Khoo, Saye; Klenerman, Paul; Law, Andrew; Lim, Wei Shen; Mentzer, Alexander J; Merson, Laura; Meynert, Alison M; Noursadeghi, Mahdad; Palmarini, Massimo; Paxton, William A; Pollakis, Georgios; Price, Nicholas; Rambaut, Andrew; Robertson, David L; Russell, Clark D; Sancho-Shimizu, Vanessa; Scott, Janet T; Silva, Thushan De; Sigfrid, Louise; Solomon, Tom; Sriskandan, Shiranee; Stuart, David; Summers, Charlotte; Tedder, Richard S; Thomson, Emma C; Roger Thompson, A A; Turtle, Lance C W; Gupta, Rishi K; Zambon, Maria; Hardwick, Hayley; Donohue, Chloe; Lyons, Ruth; Griffiths, Fiona; Norman, Lisa; Pius, Riinu; Drake, Thomas M; Fairfield, Cameron J; Knight, Stephen R; Mclean, Kenneth A; Murphy, Derek; Shaw, Catherine A; Dalton, Jo; Girvan, Michelle; Saviciute, Egle; Roberts, Stephanie; Harrison, Janet; Marsh, Laura; Connor, Marie; Halpin, Sophie; Jackson, Clare; Gamble, Carrol; Leeming, Gary; Wham, Murray; Clohisey, Sara; Hendry, Ross; Scott-Brown, James; Greenhalf, William; Shaw, Victoria; McDonald, Sara; Keating, Seán; Ahmed, Katie A; Armstrong, Jane A; Ashworth, Milton; Asiimwe, Innocent G; Bakshi, Siddharth; Barlow, Samantha L; Booth, Laura; Brennan, Benjamin; Bullock, Katie; Catterall, Benjamin W A; Clark, Jordan J; Clarke, Emily A; Cole, Sarah; Cooper, Louise; Cox, Helen; Davis, Christopher; Dincarslan, Oslem; Dunn, Chris; Dyer, Philip; Elliott, Angela; Evans, Anthony; Finch, Lorna; Fisher, Lewis W S; Foster, Terry; Garcia-Dorival, Isabel; Gunning, Philip; Hartley, Catherine; Jensen, Rebecca L; Jones, Christopher B; Jones, Trevor R; Khandaker, Shadia; King, Katharine; Kiy, Robyn T; Koukorava, Chrysa; Lake, Annette; Lant, Suzannah; Latawiec, Diane; Lavelle-Langham, Lara; Lefteri, Daniella; Lett, Lauren; Livoti, Lucia A; Mancini, Maria; McDonald, Sarah; McEvoy, Laurence; McLauchlan, John; Metelmann, Soeren; Miah, Nahida S; Middleton, Joanna; Mitchell, Joyce; Murphy, Ellen G; Penrice-Randal, Rebekah; Pilgrim, Jack; Prince, Tessa; Reynolds, Will; Matthew Ridley, P; Sales, Debby; Shaw, Victoria E; Shears, Rebecca K; Small, Benjamin; Subramaniam, Krishanthi S; Szemiel, Agnieska; Taggart, Aislynn; Tanianis-Hughes, Jolanta; Thomas, Jordan; Trochu, Erwan; Tonder, Libby Van; Wilcock, Eve; Eunice Zhang, J; Flaherty, Lisa; Maziere, Nicole; Cass, Emily; Carracedo, Alejandra Doce; Carlucci, Nicola; Holmes, Anthony; Massey, Hannah; Murphy, Lee; Wrobel, Nicola; McCafferty, Sarah; Morrice, Kirstie; MacLean, Alan; Adeniji, Kayode; Agranoff, Daniel; Agwuh, Ken; Ail, Dhiraj; Aldera, Erin L; Alegria, Ana; Angus, Brian; Ashish, Abdul; Atkinson, Dougal; Bari, Shahedal; Barlow, Gavin; Barnass, Stella; Barrett, Nicholas; Bassford, Christopher; Basude, Sneha; Baxter, David; Beadsworth, Michael; Bernatoniene, Jolanta; Berridge, John; Best, Nicola; Bothma, Pieter; Chadwick, David; Brittain-Long, Robin; Bulteel, Naomi; Burden, Tom; Burtenshaw, Andrew; Caruth, Vikki; Chambler, Duncan; Chee, Nigel; Child, Jenny; Chukkambotla, Srikanth; Clark, Tom; Collini, Paul; Cosgrove, Catherine; Cupitt, Jason; Cutino-Moguel, Maria-Teresa; Dark, Paul; Dawson, Chris; Dervisevic, Samir; Donnison, Phil; Douthwaite, Sam; DuRand, Ingrid; Dushianthan, Ahilanadan; Dyer, Tristan; Evans, Cariad; Eziefula, Chi; Fegan, Chrisopher; Finn, Adam; Fullerton, Duncan; Garg, Sanjeev; Garg, Atul; Gkrania-Klotsas, Effrossyni; Godden, Jo; Goldsmith, Arthur; Graham, Clive; Hardy, Elaine; Hartshorn, Stuart; Harvey, Daniel; Havalda, Peter; Hawcutt, Daniel B; Hobrok, Maria; Hodgson, Luke; Hormis, Anil; Jacobs, Michael; Jain, Susan; Jennings, Paul; Kaliappan, Agilan; Kasipandian, Vidya; Kegg, Stephen; Kelsey, Michael; Kendall, Jason; Kerrison, Caroline; Kerslake, Ian; Koch, Oliver; Koduri, Gouri; Koshy, George; Laha, Shondipon; Laird, Steven; Larkin, Susan; Leiner, Tamas; Lillie, Patrick; Limb, James; Linnett, Vanessa; Little, Jeff; Lyttle, Mark; MacMahon, Michael; MacNaughton, Emily; Mankregod, Ravish; Masson, Huw; Matovu, Elijah; McCullough, Katherine; McEwen, Ruth; Meda, Manjula; Mills, Gary; Minton, Jane; Mirfenderesky, Mariyam; Mohandas, Kavya; Mok, Quen; Moon, James; Moore, Elinoor; Morgan, Patrick; Morris, Craig; Mortimore, Katherine; Moses, Samuel; Mpenge, Mbiye; Mulla, Rohinton; Murphy, Michael; Nagel, Megan; Nagarajan, Thapas; Nelson, Mark; O'Shea, Matthew K; Otahal, Igor; Ostermann, Marlies; Pais, Mark; Palmieri, Carlo; Panchatsharam, Selva; Papakonstantinou, Danai; Paraiso, Hassan; Patel, Brij; Pattison, Natalie; Pepperell, Justin; Peters, Mark; Phull, Mandeep; Pintus, Stefania; Pooni, Jagtur Singh; Post, Frank; Price, David; Prout, Rachel; Rae, Nikolas; Reschreiter, Henrik; Reynolds, Tim; Richardson, Neil; Roberts, Mark; Roberts, Devender; Rose, Alistair; Rousseau, Guy; Ryan, Brendan; Saluja, Taranprit; Shah, Aarti; Shanmuga, Prad; Sharma, Anil; Shawcross, Anna; Sizer, Jeremy; Smith, Richard; Snelson, Catherine; Spittle, Nick; Staines, Nikki; Stambach, Tom; Stewart, Richard; Subudhi, Pradeep; Szakmany, Tamas; Tatham, Kate; Thomas, Jo; Thompson, Chris; Thompson, Robert; Tridente, Ascanio; Tupper-Carey, Darell; Twagira, Mary; Ustianowski, Andrew; Vallotton, Nick; Vincent-Smith, Lisa; Visuvanathan, Shico; Vuylsteke, Alan; Waddy, Sam; Wake, Rachel; Walden, Andrew; Welters, Ingeborg; Whitehouse, Tony; Whittaker, Paul; Whittington, Ashley; Papineni, Padmasayee; Wijesinghe, Meme; Williams, Martin; Wilson, Lawrence; Winchester, Stephen; Wiselka, Martin; Wolverson, Adam; Wootton, Daniel G; Workman, Andrew; Yates, Bryan; Young, Peter; Wai Ho, Antonia Ying

Venue: BMJ Open

Type: Publication

Abstract: ObjectivesThe steroid hormone vitamin D has roles in immunomodulation and bone health. Insufficiency is associated with susceptibility to respiratory infections. We report 25-hydroxy vitamin D (25(OH)D) measurements in hospitalised people with COVID-19 and influenza A and in survivors of critical illness to test the hypotheses that vitamin D insufficiency scales with illness severity and persists in survivors.DesignCross-sectional study.Setting and participantsPlasma was obtained from 295 hospitalised people with COVID-19 (International Severe ... (read more)

DOI: 10.1136/bmjopen-2021-055435