BIP! Finder - Rampant C->U hypermutation in the genomes of SARS-CoV-2 and other coronaviruses – causes and consequences for their short and long evolutionary trajectories

2020 • Rampant C->U hypermutation in the genomes of SARS-CoV-2 and other coronaviruses – causes and consequences for their short and long evolutionary trajectories

Authors: Simmonds, P.

Venue: mSphere

Type: Publication

Abstract: AbstractThe pandemic of SARS coronavirus 2 (SARS-CoV-2) has motivated an intensive analysis of its molecular epidemiology following its worldwide spread. To understand the early evolutionary events following its emergence, a dataset of 985 complete SARS-CoV-2 sequences was assembled. Variants showed a mean 5.5-9.5 nucleotide differences from each other, commensurate with a mid-range coronavirus substitution rate of 3×10−4substitutions/site/year. Almost half of sequence changes were C->U transitions with an 8-fold base frequency normalised... (read more)

Impact:

1.6222016E-7 1.0313451E-8 185 185

/ Attention: 0 4

Topics: Genetics Evolutionary biology Virology

DOI: 10.1128/msphere.00408-20

External links: Crossref OpenAIRE

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