BIP! Finder - Novel Function of Bluetongue Virus NS3 Protein in Regulation of the MAPK/ERK Signaling Pathway

2019 • Novel Function of Bluetongue Virus NS3 Protein in Regulation of the MAPK/ERK Signaling Pathway

Authors: Cindy Kundlacz, Marie Pourcelot, Aurore Fablet, Rayane Amaral Da Silva Moraes, Thibaut Léger, Bastien Morlet, Cyril Viarouge, Corinne Sailleau, Mathilde Turpaud, Axel Gorlier, Emmanuel Breard, Sylvie Lecollinet, Piet A. van Rijn, Stephan Zientara, Damien Vitour, Grégory Caignard

Venue: Journal of Virology

Type: Article

Abstract: Bluetongue virus (BTV) is responsible of the arthropod-borne disease bluetongue (BT) transmitted to ruminants by blood-feeding midges. In this report, we found that BTV, through its nonstructural protein NS3 (BTV-NS3), interacts with BRAF, a key component of the MAPK/ERK pathway. In response to growth factors, this pathway promotes cell survival and increases protein translation. We showed that BTV-NS3 enhances the MAPK/ERK pathway, and this activation is BRAF dependent. Treatment of MAPK/ERK pathway with the pharmacologic inhibitor U0126 impai... (read more)

Topics: Virology Cell biology

DOI: 10.1128/jvi.00336-19

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External links: Crossref , OpenAIRE

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