BIP! Finder - Activated MEK Stimulates Expression of AP-1 Components Independently of Phosphatidylinositol 3-Kinase (PI3-Kinase) but Requires a PI3-Kinase Signal To Stimulate DNA Synthesis

1999 • Activated MEK Stimulates Expression of AP-1 Components Independently of Phosphatidylinositol 3-Kinase (PI3-Kinase) but Requires a PI3-Kinase Signal To Stimulate DNA Synthesis

Authors: Christopher J. Marshall; Hugh Paterson; Rebecca Wilson; Steven Hooper; Iris Treinies

Venue: Molecular and Cellular Biology

Type: Publication

Abstract: To investigate the contribution that ERK/mitogen-activated protein kinase signalling makes to cell cycle progression and gene expression, we have constructed cell lines to express an inducible version of activated MEK1. Using these cells, we show that activation of MEK leads to the expression of Fra-1 and Fra-2 but not c-Fos. Treatment of Ras-transformed cells with the MEK inhibitor PD098059 blocks expression of Fra-1 and Fra-2, showing that in Ras transformation ERK signalling is responsible for Fra-1 and Fra-2 expression. Activation of MEK1 i... (read more)

Impact:

1.7702725E-8 1.5653299E-8 175 68

/ Attention: 0 79

Topics: Cell biology Molecular biology Cancer research

DOI: 10.1128/mcb.19.1.321

External links: Crossref OpenAIRE

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