ZATT (ZNF451)–mediated resolution of topoisomerase 2 DNA-protein cross-links
Authors: Matthew J. Schellenberg, Jenna Ariel Lieberman, Andrés Herrero-Ruiz, Logan R. Butler, Jason G. Williams, Ana M. Muñoz-Cabello, Geoffrey A. Mueller, Robert E. London, Felipe Cortés-Ledesma, R. Scott Williams
Abstract: Topoisomerase 2 (TOP2) creates DNA double-strand breaks to regulate DNA topology and is critical for processes such as replication and transcription. A covalent complex between TOP2 and DNA (TOP2cc) is an intermediate in the reaction that can be trapped by drugs. Schellenberg et al. show how the SUMO ligase ZATT promotes the resolution of TOP2cc by means of tyrosyl-DNA phosphoesterase 2 (TDP2), both by enhancing recruitment of TDP2 to SUMOylated TOP2 and by enhancing the hydrolase activity of TDP2. Science , this issue p. 1412
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