BIP! Finder - Transcriptional Activation ofCYP2C9,CYP1A1, andCYP1A2by Hepatocyte Nuclear Factor 4α Requires Coactivators Peroxisomal Proliferator Activated Receptor-γ Coactivator 1α and Steroid Receptor Coactivator 1

2006 • Transcriptional Activation ofCYP2C9,CYP1A1, andCYP1A2by Hepatocyte Nuclear Factor 4α Requires Coactivators Peroxisomal Proliferator Activated Receptor-γ Coactivator 1α and Steroid Receptor Coactivator 1

Authors: Celia P, Martínez-Jiménez, José V, Castell, M José, Gómez-Lechón, Ramiro, Jover

Venue: Molecular Pharmacology

Type: Publication

Abstract: Hepatocyte nuclear factor 4alpha (HNF4alpha) is a key transcription factor for the constitutive expression of cytochromes P450 (P450s) in the liver. However, human hepatoma HepG2 cells show a high level of HNF4alpha but express only marginal P450 levels. We found that the HNF4alpha-mediated P450 transcription in HepG2 is impaired by the low level of coactivators peroxisomal proliferator activated receptor-gamma coactivator 1alpha (PGC1alpha) and steroid receptor coactivator 1 (SRC1). Reporter assays with a chimeric CYP2C9-LUC construct demonstr... (read more)

Topics: Molecular biology

DOI: 10.1124/mol.106.025403

BIP! social metrics: 0 1
External links: Crossref OpenAIRE

BibTex PDF

Topic-specific impact indicators

Popularity: This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Influence: This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citation Count: This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Impulse: This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.