2006 • Transcriptional Activation of CYP2C9, CYP1A1, and CYP1A2 by Hepatocyte Nuclear Factor 4α Requires Coactivators Peroxisomal Proliferator Activated Receptor-γ Coactivator 1α and Steroid Receptor Coactivator 1
Authors: José V. Castell; Celia P. Martinez-Jimenez; M. José Gómez-Lechón; Ramiro Jover
Venue: Molecular Pharmacology
Type: Publication
Abstract: Hepatocyte nuclear factor 4alpha (HNF4alpha) is a key transcription factor for the constitutive expression of cytochromes P450 (P450s) in the liver. However, human hepatoma HepG2 cells show a high level of HNF4alpha but express only marginal P450 levels. We found that the HNF4alpha-mediated P450 transcription in HepG2 is impaired by the low level of coactivators peroxisomal proliferator activated receptor-gamma coactivator 1alpha (PGC1alpha) and steroid receptor coactivator 1 (SRC1). Reporter assays with a chimeric CYP2C9-LUC construct demonstr... (read more)
Impact:
7.255045E-9 5.262963E-9 62 15
/ Attention: 0 3
Topics:  Molecular biology
DOI: 10.1124/mol.106.025403
External links: Crossref OpenAIRE
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