Abstract: The nuclear receptor REV‐ERBα is part of the molecular clock mechanism and is considered to be involved in a variety of biological processes within metabolically active peripheral tissues as well. To investigate whether Rev‐erbα (also known as Nr1d1) in the brain plays a role in the daily variations of energy metabolism, feeding behaviour and the sleep‐wake cycle, we studied mice with global (GKO) or brain (BKO) deletion of Rev‐erbα. Mice were studied both in a light/dark cycle and in constant darkness, and then 24‐hour variations ...
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Topics: 
Endocrinology
Internal medicine