BIP! Finder - Expression of the clock gene Rev‐erbα in the brain controls the circadian organisation of food intake and locomotor activity, but not daily variations of energy metabolism

2018 • Expression of the clock gene Rev‐erbα in the brain controls the circadian organisation of food intake and locomotor activity, but not daily variations of energy metabolism

Authors: Etienne Challet; Dominique Sage-Ciocca; Satish Sen; P de Goede; Stéphanie Dumont; Andries Kalsbeek; Sophie Reibel

Venue: Journal of Neuroendocrinology

Type: Publication

Abstract: The nuclear receptor REV‐ERBα is part of the molecular clock mechanism and is considered to be involved in a variety of biological processes within metabolically active peripheral tissues as well. To investigate whether Rev‐erbα (also known as Nr1d1) in the brain plays a role in the daily variations of energy metabolism, feeding behaviour and the sleep‐wake cycle, we studied mice with global (GKO) or brain (BKO) deletion of Rev‐erbα. Mice were studied both in a light/dark cycle and in constant darkness, and then 24‐hour variations ... (read more)

Impact:

1.3620211E-8 3.1256338E-9 20 9

/ Attention: 0 26

Topics: Endocrinology Internal medicine

DOI: 10.1111/jne.12557

External links: Crossref OpenAIRE

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