BIP! Finder - Improving glycaemic control in type 2 diabetes: Stimulate insulin secretion or provide beta‐cell rest?

2017 • Improving glycaemic control in type 2 diabetes: Stimulate insulin secretion or provide beta‐cell rest?

Authors: C. Bruce Verchere; Daniël H. van Raalte

Venue: Diabetes, Obesity and Metabolism

Type: Publication

Abstract: Type 2 diabetes (T2D) is characterized by a gradual decline in pancreatic beta cell function that determines the progressive course of the disease. While beta‐cell failure is an important contributor to hyperglycaemia, chronic hyperglycaemia itself is also detrimental for beta‐cell function, probably by inducing prolonged secretory stress on the beta cell as well as through direct glucotoxic mechanisms that have not been fully defined. For years, research has been carried out in search of therapies targeting hyperglycaemia that preserve lon... (read more)

Topics: Endocrinology Internal medicine Bioinformatics

DOI: 10.1111/dom.12935

BIP! social metrics: 0 19
External links: Crossref OpenAIRE

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