Authors: Teschendorff, Andrew E., Menon, Usha, Gentry-Maharaj, Aleksandra, Ramus, Susan J., Weisenberger, Daniel J., Shen, Hui, Campan, Mihaela, Noushmehr, Houtan, Bell, Christopher G., Maxwell, A Peter, Savage, David A., Mueller-Holzner, Elisabeth, Marth, Christian, Kocjan, Gabrijela, Gayther, Simon A., Jones, Allison, Beck, Stephan, Wagner, Wolfgang, Laird, Peter W., Jacobs, Ian J., Widschwendter, Martin
Venue: Genome Research
Type: Publication
Abstract: Polycomb group proteins (PCGs) are involved in repression of genes that are required for stem cell differentiation. Recently, it was shown that promoters of PCG target genes (PCGTs) are 12-fold more likely to be methylated in cancer than non-PCGTs. Age is the most important demographic risk factor for cancer, and we hypothesized that its carcinogenic potential may be referred by irreversibly stabilizing stem cell features. To test this, we analyzed the methylation status of over 27,000 CpGs mapping to promoters of ∼14,000 genes in whole blood...
(read more)
Topics: 
Genetics
Cancer research
Loading (it may take a couple of seconds)...
Loading (it may take a couple of seconds)...