BIP! Finder - XAV-19, a Swine Glyco-Humanized Polyclonal Antibody Against SARS-CoV-2 Spike Receptor-Binding Domain, Targets Multiple Epitopes and Broadly Neutralizes Variants

2021 • XAV-19, a Swine Glyco-Humanized Polyclonal Antibody Against SARS-CoV-2 Spike Receptor-Binding Domain, Targets Multiple Epitopes and Broadly Neutralizes Variants

Authors: Bernard Vanhove; Stéphane Marot; Ray T. So; Benjamin Gaborit; Gwénaëlle Evanno; Isabelle Malet; Guillaume Lafrogne; Edwige Mevel; Carine Ciron; Pierre-Joseph Royer; Elsa Lheriteau; François Raffi; Roberto Bruzzone; Chris Ka Pun Mok; Odile Duvaux; Anne-Geneviève Marcelin; Vincent Calvez

Venue: Frontiers in Immunology

Type: Publication

Abstract: Amino acid substitutions and deletions in the Spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants can reduce the effectiveness of monoclonal antibodies (mAbs). In contrast, heterologous polyclonal antibodies raised against S protein, through the recognition of multiple target epitopes, have the potential to maintain neutralization capacities. XAV-19 is a swine glyco-humanized polyclonal neutralizing antibody raised against the receptor binding domain (RBD) of the Wuhan-Hu-1 Spike protein of SARS-CoV-2. XAV-19 ... (read more)

Impact:

1.5015628E-8 3.3489214E-9 13 13

/ Attention: 0 16

Topics: Virology Molecular biology

DOI: 10.1101/2021.04.02.437747

External links: Crossref OpenAIRE

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