Authors: Krystalyn E. Hudson, Francesca T. Bovier, Matteo Porotto, Didier Decimo, Julia Davis-Porada, Cyrille Mathieu, Francesca La Carpia, Thomas J. Connors, Debora Stelitano, Yun Zhu, Zachary C. Bitan, Emily M. Mace, Rei Matsumoto, Emma Idzikowski, Matthew R. Baldwin, Wen-Hsuan W. Lin, Pranay Dogra, Stuart P. Weisberg, Joshua I. Gray, Sandeep N. Wontakal, Stephen A. Ferrara, Branka Horvat, Peter A. Szabo, Anne Moscona, Donna L. Farber, Maya Meimei Li Poon, Eldad A. Hod, Steven B. Wells, Joshua D. Milner, Michael Chait, Flavia Dei Zotti
Venue: Nature Immunology
Type: Publication
Abstract: ABSTRACTClinical manifestations of COVID-19 caused by the novel coronavirus SARS-CoV-2 are associated with age. While children are largely spared from severe respiratory disease, they can present with a SARS-CoV-2-associated multisystem inflammatory syndrome (MIS-C) similar to Kawasaki’s disease. Here, we show distinct antibody (Ab) responses in children with MIS-C compared to adults with severe COVID-19 causing acute respiratory distress syndrome (ARDS), and those who recovered from mild disease. There was a reduced breadth and specificity o...
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