BIP! Finder - Predicted success of prophylactic antiviral therapy to block or delay SARS-CoV-2 infection depends on the drug’s mechanism of action

2020 • Predicted success of prophylactic antiviral therapy to block or delay SARS-CoV-2 infection depends on the drug’s mechanism of action

Authors: Florence Débarre; Antonio Gonçalves; Jeremie Guedj; Peter Czuppon; François Blanquart; Alan S. Perelson; Olivier Tenaillon

Venue: N/A

Type: Publication

Abstract: AbstractRepurposed drugs that are immediately available and safe to use constitute a first line of defense against new viral infections. Despite limited antiviral activity against SARS-CoV-2, several drugs are being tested as medication or as prophylaxis to prevent infection. Using a stochastic model of early phase infection, we find that a critical efficacy above 87% is needed to block viral establishment. This can be improved by combination therapy. Below the critical efficacy, establishment of infection can sometimes be prevented, most effec... (read more)

Impact:

7.906658E-9 3.3435825E-9 9 9

/ Attention: 0 18

Topics: Virology Immunology

DOI: 10.1101/2020.05.07.20092965

External links: Crossref OpenAIRE

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