BIP! Finder - Polygenic risk score of alcohol consumption predicts alcohol-related morbidity and all-cause mortality

2019 • Polygenic risk score of alcohol consumption predicts alcohol-related morbidity and all-cause mortality

Authors: Tuomo Kiiskinen, Nina Mars, Teemu Palviainen, Jukka Koskela, Pietari Ripatti, Joel T. Rämö, Sanni Ruotsalainen, Aarno Palotie, Pamela A. F. Madden, Richard J. Rose, Jaakko Kaprio, Salomaa, Pertti Makela, Aki S. Havulinna, Samuli Ripatti

Venue: N/A

Type: Publication

Abstract: AbstractObjectiveTo develop a highly polygenic risk score (PRS) for alcohol consumption and study whether it predicts alcohol-related morbidity and all-cause mortality.DesignBiobank-based prospective cohort studySettingFinnGen Study (Finland)Participants96,499 genotyped participants from the nationwide prospective FinnGen study and 36,499 participants from prospective cohorts (Health 2000, FINRISK, Twin Cohort) with detailed baseline data and up to 25 years of follow-up time.Main outcome measuresIncident alcohol-related morbidity and alcohol-re... (read more)

Topics: Demography Environmental health Internal medicine

DOI: 10.1101/652396

BIP! social metrics: 0 21
External links: Crossref , OpenAIRE

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