BIP! Finder - Polygenic risk score of alcohol consumption predicts alcohol-related morbidity and all-cause mortality

2019 • Polygenic risk score of alcohol consumption predicts alcohol-related morbidity and all-cause mortality

Authors: Tuomo Kiiskinen, Nina J. Mars, Teemu Palviainen, Jukka Koskela, Pietari Ripatti, Joel T. Rämö, Sanni Ruotsalainen, Aarno Palotie, Pamela A.F. Madden, Richard J. Rose, Jaakko Kaprio, Veikko Salomaa, Pia Mäkelä, Aki S. Havulinna, Samuli Ripatti

Venue: Biorxiv

Type: Article

Abstract: To develop a highly polygenic risk score (PRS) for alcohol consumption and study whether it predicts alcohol-related morbidity and all-cause mortality.Biobank-based prospective cohort studyFinnGen Study (Finland)96,499 genotyped participants from the nationwide prospective FinnGen study and 36,499 participants from prospective cohorts (Health 2000, FINRISK, Twin Cohort) with detailed baseline data and up to 25 years of follow-up time.Incident alcohol-related morbidity and alcohol-related or all-cause mortality, based on hospitalizations, outpat... (read more)

Topics: Demography Environmental health Internal medicine

DOI: 10.1101/652396

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External links: Crossref , OpenAIRE

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