BIP! Finder - Polygenic risk score of alcohol consumption predicts alcohol-related morbidity and all-cause mortality

2019 • Polygenic risk score of alcohol consumption predicts alcohol-related morbidity and all-cause mortality

Authors: Pertti Makela; Teemu Palviainen; Pietari Ripatti; Nina Mars; Salomaa; Samuli Ripatti; Richard J. Rose; Aarno Palotie; Jaakko Kaprio; Aki S. Havulinna; Pamela A. F. Madden; Tuomo Kiiskinen; Jukka Koskela; Sanni Ruotsalainen; Joel T. Rämö

Venue: N/A

Type: Publication

Abstract: AbstractObjectiveTo develop a highly polygenic risk score (PRS) for alcohol consumption and study whether it predicts alcohol-related morbidity and all-cause mortality.DesignBiobank-based prospective cohort studySettingFinnGen Study (Finland)Participants96,499 genotyped participants from the nationwide prospective FinnGen study and 36,499 participants from prospective cohorts (Health 2000, FINRISK, Twin Cohort) with detailed baseline data and up to 25 years of follow-up time.Main outcome measuresIncident alcohol-related morbidity and alcohol-re... (read more)

Topics: Demography Internal medicine Environmental health

DOI: 10.1101/652396

BIP! social metrics: 0 37
External links: Crossref OpenAIRE

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