BIP! Finder - The influenza A virus endoribonuclease PA-X usurps host mRNA processing machinery to limit host gene expression

2018 • The influenza A virus endoribonuclease PA-X usurps host mRNA processing machinery to limit host gene expression

Authors: Gaucherand, Lea; Porter, Brittany K.; Schmaling, Summer K.; Rycroft, Christopher Harley; Kevorkian, Yuzo; McCormick, Craig; Khaperskyy, Denys A.; Gaglia, Marta Maria

Venue: N/A

Type: Publication

Abstract: SUMMARYMany viruses globally shut off host gene expression to inhibit activation of cell-intrinsic antiviral responses. However, host shutoff is not indiscriminate, since viral proteins and host proteins required for viral replication are still synthesized during shutoff. The molecular determinants of target selectivity in host shutoff remain incompletely understood. Here, we report that the influenza A virus shutoff factor PA-X usurps RNA splicing to selectively target host RNAs for destruction. PA-X preferentially degrades spliced mRNAs, both... (read more)

Topics: Virology Cell biology

DOI: 10.1101/442996

BIP! social metrics: 0 6
External links: Crossref OpenAIRE

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