Authors: Calabrese, C, Lehmann, K, Urban, L, Liu, F, Erkek, S, Fonseca, NA, Kahles, A, Kilpinen, H, Markowski, J, Waszak, SM, Korbel, JO, Zhang, Z, Brazma, Rätsch, G, Schwarz, RF, Stegle, O
Venue: N/A
Type: Publication
Abstract: AbstractCancer is characterised by somatic genetic variation, but the effect of the majority of non-coding somatic variants and the interface with the germline genome are still unknown. We analysed the whole genome and RNA-Seq data from 1,188 human cancer patients as provided by the Pan-cancer Analysis of Whole Genomes (PCAWG) project to map cis expression quantitative trait loci of somatic and germline variation and to uncover the causes of allele-specific expression patterns in human cancers. The availability of the first large-scale dataset ...
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Topics: 
Genetics
Computational biology
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