BIP! Finder - Extracellular vesicle-based vaccine platform displaying native viral envelope proteins elicits a robust anti-SARS-CoV-2 response in mice

2020 • Extracellular vesicle-based vaccine platform displaying native viral envelope proteins elicits a robust anti-SARS-CoV-2 response in mice

Authors: K. Polak; N. Greze; M. Lachat; D. Merle; S. Chiumento; C. Bertrand-Gaday; B. Trentin; R. Z. Mamoun

Venue: N/A

Type: Publication

Abstract: AbstractExtracellular vesicles (EVs) emerge as essential mediators of intercellular communication. DNA vaccines encoding antigens presented on EVs efficiently induce T-cell responses and EV-based vaccines containing the Spike (S) proteins of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) are highly immunogenic in mice. Thus, EVs may serve as vaccine platforms against emerging diseases, going beyond traditional strategies, with the antigen displayed identically to the original protein embedded in the viral membrane and presented as suc... (read more)

Topics: Virology Cell biology Immunology

DOI: 10.1101/2020.10.28.357137

BIP! social metrics: 0 75
External links: Crossref OpenAIRE

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