Abstract: Abstract Background: Germline mutations in the MAPT gene cause some forms of frontotemporal lobar degeneration (FTLD). Recent studies show that a single mutation in MAPT can promote alternative tau misfolding pathways engendering divergent tau conforms and representing clinical heterogeneity, and that under conditions of cell-free molecular crowding the repertoire of tau forms can include liquid-liquid phase separation (LLPS). Methods: Neuronal nuclear morphologies in FTLD patients and TgTauP301L transgenic mice were analyzed by immunohistochem...
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