BIP! Finder - Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein

2020 • Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein

Authors: Zost, Seth J.; Gilchuk, Pavlo; Chen, Rita E.; Case, James Brett; Reidy, Joseph X.; Trivette, Andrew; Nargi, Rachel S.; Sutton, Rachel E.; Suryadevara, Naveenchandra; Chen, Elaine C.; Binshtein, Elad; Shrihari, Swathi; Ostrowski, Mario; Chu, Helen Y.; Didier, Jonathan E.; MacRenaris, Keith W.; Jones, Taylor; Day, Samuel; Myers, Luke; Lee, F. Eun-Hyung; Nguyen, Doan C.; Sanz, Ignacio; Martinez, David R.; Rothlauf, Paul W.; Bloyet, Louis-Marie; Whelan, Sean; Baric, Ralph S.; Thackray, Larissa B.; Diamond, Michael S.; Carnahan, Robert H.; Crowe, James E. Jr.; crowe

Venue: Nature Medicine

Type: Publication

Abstract: Antibodies are a principal determinant of immunity for most RNA viruses and have promise to reduce infection or disease during major epidemics. The novel coronavirus SARS-CoV-2 has caused a global pandemic with millions of infections and hundreds of thousands of deaths to date1,2. In response, we used a rapid antibody discovery platform to isolate hundreds of human monoclonal antibodies (mAbs) against the SARS-CoV-2 spike (S) protein. We stratify these mAbs into five major classes based on their reactivity to subdomains of S protein as well as ... (read more)

Impact: 3.8937165E-7 2.8345621E-8 468 414 / Attention: 0 25

Topics: SARS-CoV-2 and COVID-19 Research Viral gastroenteritis research and epidemiology Viral Infections and Immunology Research

DOI: 10.1101/2020.05.12.091462

External links: Crossref OpenAIRE

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