BIP! Finder - Robust ACE2 protein expression localizes to the motile cilia of the respiratory tract epithelia and is not increased by ACE inhibitors or angiotensin receptor blockers

2020 • Robust ACE2 protein expression localizes to the motile cilia of the respiratory tract epithelia and is not increased by ACE inhibitors or angiotensin receptor blockers

Authors: Lee, Ivan T; Nakayama, Tsuguhisa; Wu, Chien-Ting; Goltsev, Yury; Jiang, Sizun; Gall, Phillip A; Liao, Chun-Kang; Shih, Liang-Chun; Schurch, Christian M; McIlwain, David R; Chu, Pauline; Borchard, Nicole A; Zarabanda, David; Dholakia, Sachi S; Yang, Angela; Kim, Dayoung; Kanie, Tomoharu; Lin, Chia-Der; Tsai, Ming-Hsui; Phillips, Katie M; Kim, Raymond; Overdevest, Jonathan B; Tyler, Matthew A; Yan, Carol H; Lin, Chih-Feng; Lin, Yi-Tsen; Bau, Da-Tian; Tsay, Gregory J; Patel, Zara M; Tsou, Yung-An; Tai, Chih-Jaan; Yeh, Te-Huei; Hwang, Peter H; Nolan, Garry P; Nayak, Jayakar V; Jackson, Peter K

Venue: N/A

Type: Publication

Abstract: We investigated the expression and subcellular localization of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2 (ACE2), within the upper (nasal) and lower (pulmonary) respiratory tracts of healthy human donors. We detected ACE2 protein expression within the cilia organelle of ciliated airway epithelial cells, which likely represents the initial or early subcellular site of SARS-CoV-2 viral entry during respiratory transmission. We further determined whether ACE2 expression in the cilia of upper respiratory cells was influenced by patien... (read more)

Topics: Cell biology Internal medicine Endocrinology

DOI: 10.1101/2020.05.08.20092866

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