Authors: Muus, Christoph; Luecken, Malte D.; Eraslan, Gokcen; Waghray, Avinash; Heimberg, Graham; Sikkema, Lisa; Kobayashi, Yoshihiko; Vaishnav, Eeshit Dhaval; Subramanian, Ayshwarya; Smilie, Christopher; Jagadeesh, Karthik; Duong, Elizabeth Thu; Fiskin, Evgenij; Triglia, Elena Torlai; Ansari, Meshal; Cai, Peiwen; Lin, Brian; Buchanan, Justin; Chen, Sijia; Shu, Jian; Haber, Adam L; Chung, Hattie; Montoro, Daniel T; Adams, Taylor; Aliee, Hananeh; Samuel, J.; Andrusivova, Allon Zaneta; Angelidis, Ilias; Ashenberg, Orr; Bassler, Kevin; Bécavin, Christophe; Benhar, Inbal; Bergenstråhle, Joseph; Bergenstråhle, Ludvig; Bolt, Liam; Braun, Emelie; Bui, Linh T; Chaffin, Mark; Chichelnitskiy, Evgeny; Chiou, Joshua; Conlon, Thomas M; Cuoco, Michael S; Deprez, Marie; Fischer, David S; Gillich, Astrid; Gould, Joshua; Guo, Minzhe; Gutierrez, Austin J; Habermann, Arun C; Harvey, Tyler; He, Peng; Hou, Xiaomeng; Hu, Lijuan; Jaiswal, Alok; Jiang, Peiyong; Kapellos, Theodoros; Kuo, Christin S; Larsson, Ludvig; Leney-Greene, Michael A.; Lim, Kyungtae; Litviňuková, Monika; Lu, Ji; Ludwig, Leif S; Luo, Wendy; Maatz, Henrike; Madissoon, Elo; Mamanova, Lira; Manakongtreecheep, Kasidet; Marquette, Charles-Hugo; Mbano, Ian; McAdams, Alexi Marie; Metzger, Ross J; Nabhan, Ahmad N; Nyquist, Sarah K.; Penland, Lolita; Poirion, Olivier B; Poli, Sergio; Qi, CanCan; Queen, Rachel; Reichart, Daniel; Rosas, Ivan; Schupp, Jonas; Sinha, Rahul; Sit, Rene V; Slowikowski, Kamil; Slyper, Michal; Smith, Neal; Sountoulidis, Alex; Strunz, Maximilian; Sun, Dawei; Talavera-López, Carlos; Tan, Peng; Tantivit, Jessica; Travaglini, Kyle J; Tucker, Nathan R.; Vernon, Katherine; Wadsworth, Marc H.; Waldman, Julia; Wang, Xiuting; Yan, Wenjun; Zhao, William; Ziegler, Carly G. K.

Venue: N/A

Type: Publication

Abstract: ABSTRACTThe COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, creates an urgent need for identifying molecular mechanisms that mediate viral entry, propagation, and tissue pathology. Cell membrane bound angiotensin-converting enzyme 2 (ACE2) and associated proteases, transmembrane protease serine 2 (TMPRSS2) and Cathepsin L (CTSL), were previously identified as mediators of SARS-CoV2 cellular entry. Here, we assess the cell type-specific RNA expression ofACE2,TMPRSS2, andCTSLthrough an integrated analysis of 107 single-cell and sin... (read more)

Impact:   7.953618E-8    7.911633E-9    138    131  / Attention: 0 31

DOI: 10.1101/2020.04.19.049254