BIP! Finder - Association of Myeloid Liver Kinase B1 Depletion With a Reduction in Alveolar Macrophage Numbers and an Impaired Host Defense During Gram-Negative Pneumonia

2020 • Association of Myeloid Liver Kinase B1 Depletion With a Reduction in Alveolar Macrophage Numbers and an Impaired Host Defense During Gram-Negative Pneumonia

Authors: Natasja A Otto, Alex F de Vos, Jeroen W J van Heijst, Joris J T H Roelofs, Tom van der Poll

Venue: The Journal of Infectious Diseases

Type: Article

Abstract: Liver kinase B1 (LKB1) has been studied extensively as a tumor suppressor gene (Stk11) in the context of cancer. We hypothesized that myeloid LKB1 plays a role in innate immunity during pneumonia. Mice deficient for LKB1 in myeloid cells (LysM-cre × Stk11fl/fl) or neutrophils (Mrp8-cre × Stk11fl/fl) were infected with Klebsiella pneumoniae via the airways. LysM-cre × Stk11fl/fl mice were also intranasally challenged with lipopolysaccharide (LPS). Mice with myeloid LKB1 deficiency, but not those with neutrophil LKB1 deficiency, had increased ... (read more)

Topics: Immunology

DOI: 10.1093/infdis/jiaa416

BIP! social metrics: 0 13
External links: Crossref , OpenAIRE

References (45) Citations (9) BibTex PDF

Topic-specific impact indicators

Popularity: This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Influence: This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citation Count: This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Impulse: This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.