BIP! Finder - Association of Myeloid Liver Kinase B1 Depletion With a Reduction in Alveolar Macrophage Numbers and an Impaired Host Defense During Gram-Negative Pneumonia

2020 • Association of Myeloid Liver Kinase B1 Depletion With a Reduction in Alveolar Macrophage Numbers and an Impaired Host Defense During Gram-Negative Pneumonia

Authors: Natasja A Otto, Alex F de Vos, Jeroen W J van Heijst, Joris J T H Roelofs, Tom van der Poll

Venue: The Journal of Infectious Diseases

Type: Article

Abstract: Liver kinase B1 (LKB1) has been studied extensively as a tumor suppressor gene (Stk11) in the context of cancer. We hypothesized that myeloid LKB1 plays a role in innate immunity during pneumonia. Mice deficient for LKB1 in myeloid cells (LysM-cre × Stk11fl/fl) or neutrophils (Mrp8-cre × Stk11fl/fl) were infected with Klebsiella pneumoniae via the airways. LysM-cre × Stk11fl/fl mice were also intranasally challenged with lipopolysaccharide (LPS). Mice with myeloid LKB1 deficiency, but not those with neutrophil LKB1 deficiency, had increased ... (read more)

Topics: Immunology

DOI: 10.1093/infdis/jiaa416

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External links: Crossref , OpenAIRE

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