BIP! Finder - Fine mapping of genome-wide association study signals to identify genetic markers of the plasma triglyceride response to an omega-3 fatty acid supplementation

2019 • Fine mapping of genome-wide association study signals to identify genetic markers of the plasma triglyceride response to an omega-3 fatty acid supplementation

Authors: Bastien Vallée Marcotte; Marie-Claude Vohl; Frédéric Guénard; Patrick Couture; Philip C. Calder; Iwona Rudkowska; Anne Marie Minihane; Simone Lemieux

Venue: The American Journal of Clinical Nutrition

Type: Publication

Abstract: Using a genome-wide association study (GWAS) approach, our group previously computed a genetic risk score (GRS) from single nucleotide polymorphisms (SNPs) of 10 loci that affect the plasma triglyceride (TG) response to an omega-3 (n-3) fatty acid (FA) supplementation.The objective was to compute a novel and more refined GRS using fine mapping to include a large number of genetic variants.A total of 208 participants of the Fatty Acid Sensor (FAS) Study received 5 g fish oil/d, containing 1.9-2.2 g eicosapentaenoic acid and 1.1 g docosahexanoic ... (read more)

Impact:

1.6228286E-8 3.984715E-9 23 17

/ Attention: 0 26

Topics: Genetics Internal medicine

DOI: 10.1093/ajcn/nqy298

External links: Crossref OpenAIRE

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