Abstract: High cellularity and poorly organized tumour vasculature in high-grade gliomas leads to insufficient blood supply, hypoxic areas, and ultimately to the formation of necrosis. Thus, hypoxia is a hallmark of malignant glioma microenvironment and it is associated with aggressive tumor behavior such as growth, progression, and resistance to chemo-radiation. Current pathologic markers are insufficient to identify patients that may benefit from specific treatments. We therefore, hypothesized that underlying epigenetic alterations confer therapeutic r...
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Topics: 
Cancer research
Pathology