BIP! Finder - Association of Myeloid Liver Kinase B1 Depletion With a Reduction in Alveolar Macrophage Numbers and an Impaired Host Defense During Gram-Negative Pneumonia

2020 • Association of Myeloid Liver Kinase B1 Depletion With a Reduction in Alveolar Macrophage Numbers and an Impaired Host Defense During Gram-Negative Pneumonia

Authors: Otto, Natasja A.; de Vos, Alex F.; van Heijst, Jeroen W. J.; Roelofs, Joris J. T. H.; van der Poll, Tom

Venue: The Journal of Infectious Diseases

Type: Publication

Abstract: AbstractBackgroundLiver kinase B1 (LKB1) has been studied extensively as a tumor suppressor gene (Stk11) in the context of cancer. We hypothesized that myeloid LKB1 plays a role in innate immunity during pneumonia.MethodsMice deficient for LKB1 in myeloid cells (LysM-cre × Stk11fl/fl) or neutrophils (Mrp8-cre × Stk11fl/fl) were infected with Klebsiella pneumoniae via the airways. LysM-cre × Stk11fl/fl mice were also intranasally challenged with lipopolysaccharide (LPS).ResultsMice with myeloid LKB1 deficiency, but not those with neutrophil L... (read more)

Topics: Immunology

DOI: 10.1093/infdis/jiaa416

BIP! social metrics: 0 26
External links: Crossref OpenAIRE

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