Authors: S. Hong Lee, Enda M. Byrne, Christina M. Hultman, Anna K. Kähler, Anna A. E. Vinkhuyzen, Stephan Ripke, Ole A. Andreassen, Thomas Frisell, Alexander Gusev, Xinli Hu, Robert Karlsson, Vasilis X Mantzioris, John J. McGrath, Divya Mehta, Eli A. Stahl, Qiongyi Zhao, Kenneth S. Kendler, Patrick F. Sullivan, Alkes L. Price, Michael Conlon O'Donovan, Yukinori Okada, Bryan J. Mowry, Soumya Raychaudhuri, Naomi R. Wray, William Byerley, Wiepke Cahn, Rita M. Cantor, Sven Cichon, Paul Cormican, David Curtis, Srdjan Djurovic, Valentina Escott-Price, Pablo V. Gejman, Lyudmila Georgieva, Ina Giegling, Thomas Hansen, Andres Ingason, Yunjung Kim, Bettina Konte, Phil Lee, Andrew M. McIntosh, Andrew McQuillin, Derek W. Morris, Markus M. Nöthen, Colm O'Dushlaine, Ann Olincy, Line Olsen, Carlos N. Pato, Michele T. Pato, Benjamin S. Pickard, Danielle Posthuma, Henrik B. Rasmussen, Marcella Rietschel, Dan Rujescu, Thomas G. Schulze, Jeremy M. Silverman, Srinivasa Thirumalai, Thomas Werge, Ingrid Agartz, Farooq Amin, Maria Helena Pinto de Azevedo, Nicholas Bass, Donald W. Black, Douglas Blackwood, Richard Bruggeman, Nancy G. Buccola, Khalid Choudhury, Robert C. Cloninger, Aiden Corvin, Nicholas John Craddock, Mark J. Daly, Susmita Datta, Gary Donohoe, Jubao Duan, Frank Dudbridge, Ayman H. Fanous, Robert Freedman, Nelson B. Freimer, Marion Friedl, Michael Gill, Hugh Gurling, Lieuwe de Haan, Marian L. Hamshere, Annette M. Hartmann, Peter Holmans, René S. Kahn, Matthew C. Keller, Elaine Kenny, George Kirov, Lydia Krabbendam, Robert Krasucki, Jacob Lawrence, Todd Lencz, Douglas F. Levinson, Jeffrey A. Lieberman, Danyu Lin, Don H. Linszen, Patrik K. E. Magnusson, Wolfgang Maier, Anil K. Malhotra, Manuel Mattheisen, Morten Mattingsdal, Steven A. McCarroll, Helena Medeiros, Ingrid Melle, Vihra Milanova, Inez Myin-Germeys, Benjamin M. Neale, Roel A. Ophoff, Michael John Owen, Jonathan Pimm, Shaun Purcell, Vinay Puri, Digby Quested, Lizzy Rossin, Douglas M. Ruderfer, Alan R. Sanders, Jianxin Shi, Pamela Sklar, David St Clair, T. Scott Stroup, Jim van Os, Peter M. Visscher, Durk Wiersma, Stanley Zammit, S. Louis Bridges, Hyon K. Choi, Marieke J H Coenen, Niek de Vries, Philippe Dieud, Jeff Greenberg, Tom W J Huizinga, Leonid Padyukov, Katherine A. Siminovitch, Paul P. Tak, Jane Worthington, Philip L. De Jager, Joshua C. Denny, Peter K. Gregersen, Lars Klareskog, Xavier Mariette, Robert M. Plenge, Mart A F J van de Laar, Piet L. C. M. van Riel
Venue: International Journal of Epidemiology
Type: Publication
Abstract: PUBLISHED Background: A long-standing epidemiological puzzle is the reduced rate of rheumatoid arthritis (RA) in those with schizophrenia (SZ) and vice versa. Traditional epidemiological approaches to determine if this negative association is underpinned by genetic factors would test for reduced rates of one disorder in relatives of the other, but sufficiently powered data sets are difficult to achieve. The genomics era presents an alternative paradigm for investigating the genetic relationship between two uncommon disorders. Methods: We use ge...
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