BIP! Finder - Fast and accurate short read alignment with Burrows

2009 • Fast and accurate short read alignment with Burrows–Wheeler transform

Authors: Richard Durbin; Heng Li

Venue: Bioinformatics

Type: Publication

Abstract: Abstract Motivation: The enormous amount of short reads generated by the new DNA sequencing technologies call for the development of fast and accurate read alignment programs. A first generation of hash table-based methods has been developed, including MAQ, which is accurate, feature rich and fast enough to align short reads from a single individual. However, MAQ does not support gapped alignment for single-end reads, which makes it unsuitable for alignment of longer reads where indels may occur frequently. The speed of MAQ is also a concern wh... (read more)

Topics: Data mining Algorithm

DOI: 10.1093/bioinformatics/btp324

BIP! social metrics: 1 131
External links: Crossref OpenAIRE

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